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Perfopil is a medication effective for treating male sexual disability. Perfopil is a blue tablet manufactured in 25, 50, 100 and 150 mg tablets for treating erectile dysfunction. Having been around for a lot longer, Perfopil has a great safety track record and proven effects that start acting in 30 minutes and last for about 5 hours.

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Product description

Drug Name

Perfopil (Sildenafil)

Drug Uses

Perfopil is used for treating erectile dysfunction (e.g. male impotence). It works by helping the blood flow into the penis to achieve and maintain an erection during sexual stimulation.

How to use

Perfopil is to be taken 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Perfopil is not supposed to be taken more often than once per day.

Drug Class and Mechanism

Perfopil is a phosphodiesterase type 5 inhibitor and it works by helping the blood flow into the penis to achieve and maintain an erection during sexual stimulation.

Missed Dose

Perfopil is to be used as necessary, so you are not supposed to take it according to a schedule.


Perfopil is to be kept in its original container. It is to be stored at room temperature between 59 and 86 degrees F (15-30 degrees C) away from moisture, heat and light and out of the reach of children.

Safety information


Do not take Perfopil, if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers").

Before taking Perfopil, tell your doctor about all other medications you use for erectile dysfunction, or if you are using any of the following medications:

  • bosentan (Tracleer);
  • a blood thinner such as warfarin (Coumadin);
  • cimetidine (Tagamet, Tagamet HB);
  • an antibiotic such as erythromycin (E-Mycin, Eryc, Ery-Tab) or clarithromycin (Biaxin);
  • doxazosin (Cardura), prazosin (Minipress), Terazosin (Hytrin);
  • HIV medicines such as amprenavir (Agenerase), tipranavir (Aptivus), darunavir (Prezista), efavirenz (Sustiva), nevirapine (Viramune), indinavir (Crixivan), saquinavir (Invirase, Fortovase), lopinavir/ritonavir (Kaletra), fosamprenavir (Lexiva), ritonavir (Norvir), atazanavir (Reyataz), or nelfinavir (Viracept);
  • an antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
  • carbamazepine (Tegretol), phenobarbital (Luminal), or phenytoin (Dilantin); or
  • rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).
    • Tell your doctor about all the prescriptions and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

      If you have heart problems severe enough to make sexual activity a dangerous, you should avoid using Perfopil. Use it cautiously, if you've had a heart attack, stroke, or life-threatening heart irregularities within the past 6 months. Be equally cautious, if you have severe high or low blood pressure, heart failure or unstable angina.

      In case of cardiac symptoms developing (for example, dizziness, nausea, and chest pain) during sexual activity, do not continue. Tell your doctor about the problem as soon as possible.

      If you have a condition that might result in long-lasting erections, such as sickle cell anemia, multiple myeloma (a disease of the bone marrow), or leukemia, use Perfopil with caution. Also use cautiously if you have a genital problem or deformity such as Peyronie's disease. If an erection lasts more than 4 hours, seek treatment immediately. Permanent damage and impotence could result.

      If you have a bleeding disorder, a stomach ulcer, or the inherited eye condition known as retinitis pigmentosa, use Perfopil with caution. Its safety under these circumstances has not been studied yet.

      Side Effects

      Possible Side Effects

      If you experience any of the following serious side effects, stop taking Perfopil and seek emergency medical attention or notify your doctor immediately:

      • sudden vision loss;
      • ringing in your ears, or sudden hearing loss;
      • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
      • irregular heartbeat;
      • swelling in your hands, ankles, or feet;
      • shortness of breath;
      • vision changes;
      • feeling light-headed, fainting; or
      • penis erection that is painful or lasts 4 hours or longer.

      Less serious side effects may include:

      • warmth or redness in your face, neck, or chest;
      • stuffy nose;
      • headache;
      • upset stomach; or
      • back pain.

      This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

      More Information

      If you are older than 65 years, you can suffer Perfopil side effects. However, your physician may prescribe you a lower dose of this medication.

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